Fbn1C1041G/+
Description:
The Fbn1C1041G/+ mouse model, which mimics Marfan syndrome, when crossbred with LDL receptor-deficient (LDLR-/-) or apoE-deficient (ApoE-/-) mice and fed a high-fat diet, develops human-like advanced atherosclerotic unstable plaques, characterized by exacerbated atherosclerosis, with larger necrotic cores, thinner fibrous caps, and increased plaque vulnerability.
| Date Model Generated | 11-Sep-2026 |
|---|---|
| Randomized | |
| Open for Collab. | YES |
| Species | Mouse |
| Genetic Modification | Transgenic |
| Genetic Background | C57BL/6J |
| Method of Modification | Homologous Recombination in ES cells |
| Disease Model | Other |
| Cre Recombinase | Not used |
| Zygosity | Heterozygote |
| Availability | Breeding pair |
| Data type | RNA-seq. |
| Repository | None |
Inventory Institutions
No Record Found.
Inventory Publications
No Record Found.